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Effects of ω-3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome

01.02.2022
The mechanism of action of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) is only partially known. Prior reports suggest a partial rescue of clinical symptoms and oxidative stress (OS) alterations following ω-3 PUFAs supplementation in patients with Rett syndrome (RTT), a devastating neurodevelopmental disorder with transient autistic features, affecting almost exclusively females and mainly caused by sporadic mutations in the gene encoding the methyl CpG binding protein 2 (MeCP2) protein.

Abstract
Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have received an increasing attention by the scientific community and the society as well due to their status of natural molecules with a number of claimed positive effects on a large variety of conditions, in particular in the prevention of cardiovascular disease. Most common omega-3 PUFAs are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish oil and alpha-linolenic acid C18:3 n-3, derived from plants. The hypotriglyceridemic effect is the best defined metabolic action of omega-3 PUFAs, with a mechanism likely to be related to activation of peroxisome proliferator-activated receptors.

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